Fildena (sildenafil)

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Brand(s): Fildena

Manufacturer: Fortune Health Care

What is Fildena?

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The Fildena is a drug that restores erectile function in men with impotence. It is the first of its kind and acts selectively on the penis. This is not a hormone or an aphrodisiac.

Fildena products can easily be identified by their varying blister pack color. All the three blister pack covers have different unique colors. Even the pills are pleasingly colorful and innovative shaped. Fildena product stands out from the rest when it comes to style, as it has its own premium class.

Is it a safe drug?

Yes, it is. Fildena was tested in 4,500 people in clinical tests. The incidence of adverse side effects causing patients to abandon the treatment was equal to that of patients taking placebo.

Pharmacodynamics

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence. During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis. Fildena is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of Fildena.

How does the pill?

Fildena works by increasing the relaxation of the muscles of the penis. When an erection occurs, the smooth muscles of the penis and arteries surrounding the body should be relaxed. Fildena maximizes the relaxation and increases the efficiency of erection. The enzyme on which the drug is is the phosphodiesterase type 5 (PDE-5), which is almost exclusively in the penis. More information here.

Mechanism of action

Fildena inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Fildena enhances erectile function by increasing the amount of cGMP.

What medicine is best? Fildena or Tadalista?

Both drugs were developed to treat erectile dysfunction, but they contain different active agents. This means that one of these treatments may suit you more than the other. Fildena has different benefits that Tadalista.
During the medical consultation, the doctor will determine which of these options suits you.

What are the side effects of Fildena?

Slight headache, flushing, indigestion, runny nose, transient visual disturbances (blue haze).

Will Fildena affect my visual acuity (blurry vision)?

No, it has been extensively tested.

Will Fildena affect my night vision while driving?

No, it has also been widely tested.

Are there any serious side effects?

No. The incidence of serious cardiovascular side effects in over 4500 men studied was equal in the placebo group and one in treatment; less than 2%. There were no deaths during the studies.

Is this drug causes permanent erection (priapism)?

No. Fildena does not cause an erection without sexual stimulation, in contrast to injections into the penis or intraurethral therapy. Its mechanism of action is totally different.

Are there any cons-indications?

Yes. The only cons-indication is taking nitrates (nitroglycerin sublingual, long-acting nitrates, nitrate pastes). Several patients have fainted while taking nitrates and Fildena because of the drop in blood pressure. No patient suffered serious consequences after fainting. If you take nitrates, consult your physician or cardiologist before considering this medication.

Which drugs or supplements interact with sildenafil?

Fildena increases the effects of the blood pressure lowering medications. It also increases the blood pressure lowering effects of nitrates, for example, isosorbide dinitrate (Isordil), isosorbide mononitrate (Imdur, Ismo, Monoket), nitroglycerin (Nitro-Dur, Transderm-Nitro) that are used primarily for treating angina. Patients taking nitrates should not receive Fildena.

Patients should not combine Fildena with other PDE5 inhibitors (for example, vardenafil [Vidalista], tadalafil [Cialis]).

Cimetidine (Tagamet), erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), atazanavir (Reyataz), and mibefradil (Posicor) can cause marked increases in the amount of Fildena in the body. Patients taking these medications should be observed carefully if sildenafil is used.

It is expected that Rifampin will decrease blood levels of Fildena and probably reduce its effectiveness.

Are there a minimum or maximum age to take Fildena?

Fildena has been tested and proven to be safe in men aged 85 years maximum. Fildena has not been tested in men younger than 18 years. It is not stated in the pediatric age group

How should I take Fildena?

Take Fildena exactly as it was prescribed for you Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Fildena is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Do not take Fildena more than once per day.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Fildena can help you have an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor’s instructions.

During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of Fildena.

Will I get a spontaneous erection in 60 minutes?

No. Again, the pill is parallel to a natural sexual stimulation.

What happens if I do not have sex in the next hour?

The beneficial effect can be observed 8 hours later. Most of the time, the effect occurs within the first 4 hours. You will not get erection without sexual stimulation.

How often can I take Fildena in one day?

The recommended dosage is once a day.

Do I take two Fildena tablets at the same time?

No. You can only take one tablet at a time, respect the prescribed dosage.

What dose should I take? Are there different dosages?

A tablet of Fildena is available in 25 mg, 50 mg and 100 mg. You should take the lowest dose to start. The higher the dose, the greater the side effects are important. You can always increase or decrease your dose depending on your response to the drug. 100 mg is the maximum daily dose.

Can I overdose treatment?

More swallowed the dose during clinical trials was high, were more problematic side effects. In some Canadian trials, a dose of 200 mg was administered without improving treatment efficacy and with more side effects. Fildena has been administered in doses 8 times the recommended dose without causing major health problems.

Does the medication affect my orgasm?

No. Since the effectiveness of Fildena depends on the sexual stimulation, orgasms are not affected.

Do I fear this treatment if I’m trying to have a child?

There is no absolute answer to that question and caution is advised. This specific issue has not been studied in clinical trials. The laboratories found no effect of Fildena on sperm motility and or fertility or increased birth defects in animals.

Fildena does it cause cancer?

No. Extensive testing in animals revealed no sign of cancer.

Does this pill increase my libido (sex drive) or my aggression?

No. Fildena has no effect on libido. Extensive psychological testing showed no aggressive behavior or increased desire.

Does Fildena Work?

The drug’s effectiveness depends on the cause of the problem. If there is a serious lack of blood flow, the drug will probably not work. Clinical trials of the drug have shown that Fildena conventional dose (50mg) is effective in over 70% of patients. The lowest dose (25mg) was effective in 63% of customers, while Fildena 100mg offered an efficiency of 82%.
Diabetic men who have had prostate surgery or radical bladder surgery have a lower efficiency rate.

What if Fildena does not work?

Fildena will not work without sexual stimulation. You may be too tired or insufficiently sexually excited. If repeatedly it does not work, we advise you to consult a doctor to discuss alternatives to Fildena.

Can Fildena be taken by women?

Health authorities have not approved Fildena for women . Its safety and efficacy have not been established in another group other than men over 18 years.

Pulmonary Arterial Hypertension

PO: 5 mg or 20 mg 3 times daily, administered 4-6 hours apart
IV: 2.5-mg or 10-mg bolus 3 times daily if patient is temporarily unable to take PO
Recommended PO/IV dose not to be exceeded
Adding Fildena to bosentan does not have any beneficial effect on exercise capacity
Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy
Compared with healthy younger volunteers, healthy elderly volunteers (≥65 years) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively